西北师范大学
A UCSF study has revealed new information about how the brain directs the body to make movements. The key factor is “noise” in the brain’s signaling, and it helps explain why all movement is not carried out with the same level of precision.Understanding where noise arises in the brain has implications for advancing research in neuromotor control and in developing therapies for disorders where control is impaired, such as Parkinson’s disease.The new study was developed “to understand brain machinery behind such common movements as typing, walking through a doorway or just pointing at an object,” says Stephen Lisberger, PhD, senior study investigator who is director of the W. M. Keck Center for Integrative Neuroscience at the University of California, San Francisco. Study co-investigators are Leslie C. Osborne, PhD, a postdoctoral fellow at UCSF, and William Bialek, PhD, professor of physics at Princeton University.The study findings, reported in the September 15 issue of the journal Nature, are part of ongoing research by Lisberger and colleagues on the neural mechanisms that allow the brain to learn and maintain skills and behavior. These basic functions are carried out through the coordination of different nerve cells within the brain’s neural circuits. “To make a movement, the brain takes the electrical activity of many neurons and combines them to make muscle contractions,” Lisberger explains. “But the movements aren’t always perfect. So we asked, what gets in the way?” The answer, he says, is “noise”, which is defined as the difference between what is actually occurring and what the brain perceives. He offers making a foul shot in basketball as an example. If there were no noise in the neuromotor system, a player would be able to perform the same motion over and over and never miss a shot.“Understanding how noise is reduced to very precise commands helps us understand how those commands are created,” says Lisberger, who also is a Howard Hughes Medical Institute investigator and a UCSF professor of physiology.In the study, the research team focused on a movement that all primates are very skilled at: an eye movement known as “smooth pursuit” that allows the eyes to track a moving target. In a series of exercises with monkeys in which the animals would track visual targets, the researchers measured neural activity and smooth pursuit eye movements. From this data, the team analyzed the difference between how accurately the animals actually tracked a moving object and how accurately the brain perceived the trajectory. Findings showed that both the smooth pursuit system and the brain’s perceptual system were nearly equal.“This teaches us that these very different neural processes are limited to the same degree by the same noise sources,” says Lisberger. “And it shows that both processes are very good at reducing noise.” He concludes, “Because the brain is noisy, our motor systems don’t always do what it tells us to. Making precise movements in the face of this noise is a challenge.”1.Of the following movements instructed by the brain, which one is NOT mentioned in the article?2.How does the brain direct a body movement?3.How does “noise” affect a basketball player’s performance?4.Which of the following titles doesn’t belong to Stephen Lisberger?5.The findings of the study with monkeys show that( ).
Letter-writing goes back to thousands of years but heated up during the Middle Ages and Renaissance. Historically (perhaps now) letters were indicators of status and breeding. Like conversation, they were used to manipulate, embellish, entertain, threaten, seduce and of course do business. On the way home from discovering America, Christopher Columbus got caught in a storm and his mind turned—as a good bourgeois parent—to his two sons. Who would pay their school fees if he came to a watery end? He picked up a quill and documented his accomplishments on the voyage for his Spanish patrons, King Ferdinand and Queen Isabella, rolled up the letter in a wooden Madeira cask and threw it into the sea. This was not so much for posterity but rather what University of York professor William H. Sherman has called “a father’s desperate petition for the future support of his children.”The 18th century was strong on the epistolary book, which made authors’ quarrels especially amusing. Tobias Smollett wrote Travels Through France & Italy (my favorite letter contains his description of French women: “As their faces are concealed under a false complexion, so their heads are covered with a vast load of false hair, frizzled at the forehead, so as exactly to resemble the woolly heads of the Guinea negroes”). His approach to anything foreign was considered so full of spleen by author Laurence Sterne that he was moved to write A Sentimental Journey. This satirical novel gives Smollett the name Smelfungus—a cantankerous man addicted to exaggeration, who talks of being “flay’d alive” by cannibals: “I’ll tell it, cried Smelfungus, to the world. You had better tell it, said I, to your physician.” Samuel Johnson, in referring to his own letters, claims “...his soul lies naked” but he had doubts about the truthfulness of others, writing that there was “no transaction which offers stronger temptations to fallacy and sophistication than epistolary intercourse.”How-to books abounded. Letters, apart from business ones, were seen as a feminine task, and templates addressed feminine problems. The New Academy of Complements, for example, published in 1671, titled the letter to be written by abandoned women “A Crack’t Virgin to Her Deceitful Friend.” Hand-writing is the motif. “Now you appear so foul, that nothing can be more monstrous; is this the fruit of your Promises and Vows... how comes it then to pass, that you forsake me, ruin my Reputation, and leave me to become the Map of Shame and Ignominy…” I long to use the Map of Shame bit but I suspect it was as unhelpful then as boiling bunnies is now.A Vanderbilt University study ways children taught cursive writing learn and express themselves better. If so, I have a few suggestions for our educators. How about letters “On Reprimanding a Person of Difference Without Incurring Hate Charges”, or “An Ailing Citizen to His Callous Minister of Health.” The possibilities are, sadly, limitless.1.Letter-writing( ).2.A Sentimental Journey by Laurence Sterne( ).3.Samuel Johnson( ).4.The third paragraph suggested that( ).5.At the end of the article, the author suggested that( ).
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